MilliporeSigma™ TERT, Mouse, Unlabeled, Clone: 7D5.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE662-Each-of-1 | In Stock | ₹ 50,816.33 |
MABE662 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,816.33
GST (18%): ₹ 9,146.939
Total Price: ₹ 59,963.269
Antigen
TERT
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O14746
Immunogen
KLH-conjugated linear peptide corresponding to a sequence toward the end of the C-terminal extension (CTE) region of human TERT.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_937983
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
7D5.2
Conjugate
Unconjugated
Gene
TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TRT
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 7D5.2 targets a sequence toward the end of the C-terminal extension (CTE) region present in spliced isoforms 1 and 3, but not in isoforms 2 and 4 of human TERT reported by UniProt (O14746).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Telomerase reverse transcriptase (EC 2.7.7.49; UniProt O14746; also known as hEST2, hTRT, Telomerase-associated protein 2, Telomerase catalytic subunit, TP2) is encoded by the TERT (also known as CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TRT) gene (Gene ID 7015) in human
- Telomerase reverse transcriptase (TERT) is the catalytic subunit of the telomerase responsible for adding TTAGGG repeats to the chromosome telomere ends
- Cells with low or no telomerase expression lose telomere repeats during cell division, eventually resulting in cellular senescence
- Most cancer cells, germ cells and embryonic stem cells express high levels of telomerase, thus contributing to pluripotency and immortality
- In addition to its telomere maintenance function, telomerase also has a pro-survival role in cellular resistance against DNA damage and ensuing apoptosis
- Most cancer cells are highly proliferative and express high levels of nuclear telomerase activity
- Studies show that TERT shuttles from the nucleus into mitochondria upon oxidative stress induction in cancer cells
- TERT mitochondrial localization helps prevent nuclear DNA damage by decreasing mitochondrial reactive oxygen species (ROS), accounting for high stress resistance especially among the cancer stem cells (CSCs) population
- Following exposure to H2O2 or gamma-irradiation, cancer cells capable of excluding TERT from the nucleus display little or no DNA damage, while TERT nuclear retainment results in high DNA damage.