MilliporeSigma™ APC4, Mouse, Unlabeled, Clone: CIV1.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1257MI-Each-of-1 | In Stock | ₹ 40,228.00 |
MABS1257MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,228.00
GST (18%): ₹ 7,241.04
Total Price: ₹ 47,469.04
Antigen
APC4
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal antibody IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9UJX5
Immunogen
Linear peptide corresponding to human APC4 C-terminal end sequence.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_037499
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Clone
CIV1.1
Conjugate
Unconjugated
Gene
ANAPC4, APC4
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone CIV1.1 target human APC4 C-terminal end sequence present in spliced isoforms 1 and 3, but absent in isoform 2 reported by UniProt (Q9UJX5).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anaphase-promoting complex subunit 4 (UniProt Q9UJX5; also known as APC4, Cyclosome subunit 4) is encoded by the ANAPC4 (also known as APC4) gene (Gene ID 29945) in human
- APC4 is a component of the anaphase-promoting complex or cyclosome (APC/C)
- APC/C is an E3 ubiquitin ligase complex that promotes the transition from metaphase to anaphase of the cell cycle by targeting specific proteins for proteasomal degradation at specific times under the control of the spindle assembly checkpoint (SAC)
- The catalytic core of the APC/C consists of the cullin subunit APC2 and RING H2 domain subunit APC11
- Other APC/C components, including APC4, are composed multiple repeat motifs with the main purpose of providing molecular scaffold support
- APC4 contains WD repeats and has a molecular weight of approximately 92 kDa
- APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.