MABE439MI
MilliporeSigma™ Mouse anti-GATA6, Clone: 1G2.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE439MI-Each-of-1 | In Stock | ₹ 33,998.00 |
MABE439MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,998.00
GST (18%): ₹ 6,119.64
Total Price: ₹ 40,117.64
Antigen
GATA6
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Gene Symbols
GATA6
Immunogen
KLH-conjugated linear peptide corresponding to human GATA6.
Quantity
100 μL
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_005248
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgM κ
Applications
Western Blot
Clone
1G2.2
Gene Accession No.
Q92908
Host Species
Mouse
Purification Method
Purified by Ion-Exchange Chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects GATA6 clone: 1G2.2 in Human samples, and it is validated for Western Blotting GATA-6 is a developmental transcriptional activator important in terminal differentiation and proliferation of cells destined to be associated with the heart, gut and gut related tissues and organs
- GATA-6 works in concert with SEMA3C and PLXNA2 transcription factors and regulates the expression of their target genes
- GATA-6 is particularly important in heart development as a number of genetic mutations within GATA-6 give rise to defective syndromes involving the heart or the vessels of the heart
- Interestingly, recent research into pulmonary hypertension disease in adults points to a critical role of GATA-6 expression in endothelial cells lining the blood vessels
- Healthy blood vessels express GATA-6 very strongly but expression is lost during vascular injury and markedly down regulated in the endothelial cells found in diseased vessels
- Because GATA-6 is a direct transcriptional regulator or important vascular proteins such as endothelin-1 receptor, endothelial nitric oxide synthase, and cytokines such as Fractalkine, GATA-6’s role in modulating the effects of pulmonary hypertension and other vascular syndromes is a subject of much research.