MABN746MI
MilliporeSigma™ Mouse anti-Prestin, Clone: 3A2.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN746MI-Each-of-1 | In Stock | ₹ 42,114.80 |
MABN746MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,114.80
GST (18%): ₹ 7,580.664
Total Price: ₹ 49,695.464
Antigen
Prestin
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Gene Symbols
SLC26A5; PRES
Immunogen
Linear peptide corresponding to human Prestin.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001161434
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgM κ
Applications
Western Blot
Clone
3A2.2
Gene Accession No.
P58743
Host Species
Mouse
Purification Method
Purified by Ion-Exchange Chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse
Form
Purified
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Description
- Specifically detects Prestin clone: 3A2.2 in Mouse samples, and it is validated for Western Blotting Prestin is a motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ
- Prestin is a bidirectional voltage-to-force converter that can operate at microsecond rates
- It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate to translocate anions toward or away from the extracellular plasma membrane surface
- As a consequence, this translocation triggers conformational changes in Prestin that ultimately alter its surface area in the plane of the plasma membrane
- Prestin acts as an incomplete transporter
- It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space and in that process it helps to modulate the electro-physical signals necessary for hearing
- Prestin is expressed in outer hair cells and localized to the cell membrane
- Mutations in Prestin can lead to deafness.