MilliporeSigma™ Cereblon, Mouse, Unlabeled, Clone: 3B12F7,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1780MI-Each-of-1 | In Stock | ₹ 42,161.08 |
MABN1780MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,161.08
GST (18%): ₹ 7,588.994
Total Price: ₹ 49,750.074
Antigen
Cereblon
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q96SW2
Immunogen
KLH-conjugated linear peptide corresponding to a sequence near the N-terminus of human cereblon.
Quantity
100 μL
Research Discipline
Apoptosis & Cancer
Gene ID (Entrez)
NP_057386
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
3B12F7
Conjugate
Unconjugated
Gene
CRBN, AD-006, MRT2A
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3B12F7 was raised against an N-terminal sequence present in human cereblon spliced isoforms 1&2 and murine cereblon spliced isoforms 1&3 (UniProt Q96SW2 and Q8C7D2). Immunogen sequence is well conserved in essentially all mammalian species.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Protein cereblon (UniProt Q96SW2) is encoded by the CRBN (also known as AD-006, MRT2A) gene (Gene ID 51185) in human
- Originally identified as a genetic cause of inherited autosomal recessive mental retardation, the human CRBN gene encodes a substrate receptor of a ubiquitin E3 cullin 4-RING ligase (CRL4) complex
- A cullin-4 (CULT4) protein provides a scaffold for assembling RING box-domain protein (RBX1) and the adaptor protein damaged DNA-binding protein 1 (DDB1) to form a CRL4 E3 complex, where RBX1 serves as the docking site for the activated E2 protein, and DDB1 recruits substrate-specificity receptors or DCAFs (DDB1-cullin 4-associated factors) to form the substrate-presenting side of the CRL4 complex
- Thalidomide and its analogs (lenalidomide, pomalidomide and apremilast) are immunomodulatory drugs (IMiDs) that exert their antiproliferative effects on multiple myeloma (MM) cells and immunomodulatory effects on T cells by directly binding cereblon and promoting recruitment of the hematopoietic zinc-finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), leading to their ubiquitination and proteasomal degradation
- Human cereblon is a 442-amino acid protein composed of a Lon protease-like scaffold (a.a
- 80-317) with a helical insertion that mediates DDB1 binding and a thalidomide-binding domain (TBD; a.a
- 339-442).