MilliporeSigma™ CD84/Slamf5, Rat, Unlabeled, Clone: 1D3,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF929MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABF929MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
CD84/Slamf5
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q18PI6
Immunogen
Human IgG1 Fc-tagged recombinant mouse CD84 extracellular domain.
Quantity
100 μg
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_038517.1
Target Species
Mouse
Form
Purified
Applications
Flow Cytometry
Clone
1D3
Conjugate
Unconjugated
Gene
Cd84, Slamf5
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1D3 immunostained the surface of murine CD84-transfected, but not untranfected, BI-141 murine T-cells (Cruz-Munoz, M.E., et al. (2009). Nat. Immunol. 10(3):297-305). Reactivity toward spliced isoform 2 has not been determined.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- SLAM family member 5 (UniProt Q18PI6; also known as Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84) is encoded by the Cd84 (also known as Slamf5) gene (Gene ID 12523) in murine species
- CD84 belongs to the 7-member (SLAM/CD150, CD48/SLAMF2, Ly-9/CD229, 2B4/CD244, CD84/SLAMF5, Ly108/NTB-A/CD352, CRACC) signaling lymphocytic activation molecule family (SLAMF) of receptors broadly expressed in hematopoietic cells
- 2B4 and CD48 interact with eath other, while rest of the family members act as self-ligands, where two identical molecules on the surface of two different cells can interact as receptor and ligand to each other
- SLAMF members carry one or more copies of immunoreceptor tyrosine-based switch motif or ITSM (TxYxxV/I) in their cytoplasmic tails
- Upon phosphorylation on the tyrosine residue, ITSM mediates the recruitment of SH2 domain-containing signaling molecules such as SLAM-associated protein (SAP), including SAP in T-, NK, and NK T-cells, EAT-2A and EAT-2B (murine) in NK cells and APCs
- Murine CD84 is produced with a signal peptide sequence (a.a
- 1-21), the removal of which yields the mature CD84 with an extracellular region (a.a
- 22-221) that contains a V-type Ig-like domain (a.a
- 26-129) and a C2-type Ig-like domain (a.a
- 132-206), followed by a single transmembrane (a.a
- 222-242) and a cytoplasmic tail (a.a
- 243-329) with two copies of ITSM (a.a
- 263-268 and 298-303)
- Alternative splicings produce three CD84 isoforms, with spliced isoform 2 produced as a truncated extracellular domain with an alternative C-terminal sequence (from 128-RLKTPKITQSLIS-140 to 128-KLWQHGALDLLLI-140) and no transmembrane or cytoplasmic sequence (a.a
- 141-329 missing).