MABT177MI
MilliporeSigma™ Syndecan-1, Mouse, Unlabeled, Clone: 11G2.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT177MI-Each-of-1 | In Stock | ₹ 37,825.00 |
MABT177MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
Syndecan-1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P18827
Immunogen
GST-tagged recombinant human Syndecan-1 extracellular domain fragment.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_001006947
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
11G2.1
Conjugate
Unconjugated
Gene
SDC1, SDC
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 11G2.1 recognizes an extracellular epitope.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Syndecan-1 (UniProt P18827; also known as CD138, SYND1) is encoded by the SDC1 (also known as SDC) gene (Gene ID 6382) in human
- Syndecan-1 belongs to a family of transmembrane heparan sulfate proteoglycans (HSPGs), members of which also include syndecan-2 (fibroglycan, SDC2), syndecan-3 (N-syndecan, SDC3), and syndecan-4 (amphiglycan, ryudocan, SDC4)
- Syndecan-1 is produced with a signal peptide (a.a
- 1-22), the removal of which yields the mature protein with a large extracellular region (a.a
- 23-254), a transmembrane segment (a.a
- 255-275), and a cytoplasmic tail (a.a
- 276-310)
- Syndecan-1 is modified at its extracellular domain on a.a
- 45 and 47 with O-linked heparan sulfate (HS) that plays an important role in mediating its interaction with HS-binding protein, including growth factors (e.g
- bFGF/FGF2, PDGF, TGF-β, and VEGF) and extracellular matrix proteins (e.g
- collagens, fibronectin, thrombospondin, and tenascin)
- Syndecan-1 thus funtions as a coreceptor for growth factor receptors and acts as an anchor connecting the extracellular matrix to the intracellular cytoskeleton
- Syndecan extracellular domain can be proteolytically cleaved off at a juxtamembrane site and upregulated shedding of the ectodomain occurs in response to growth factors, chemokines, heparanase, microbial toxins, insulin, and cellular stress
- SDC1 deregulation contributes to cancer progression by promoting angiogenesis and cancer cell proliferation, metastasis, and invasion.