MilliporeSigma™ PECAM-1, Mouse, Unlabeled, Clone: 4A8.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT533-Each-of-1 | In Stock | ₹ 44,393.20 |
MABT533 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,393.20
GST (18%): ₹ 7,990.776
Total Price: ₹ 52,383.976
Antigen
PECAM-1
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P16284
Immunogen
GST-tagged recombinant human PECAM-1 cytoplasmic domain.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_000433
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
4A8.1
Conjugate
Unconjugated
Gene
PECAM1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 4A8.1 was raised against the cytoplasmic domain of PECAM-1 (CD31) isoform Long. Reactivity toward spliced isoforms Delta12, Delta13, Delta14, Delta14-15, and Delta15 with various cytomplasmic domain deletions is possible, but has not not been confirmed.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Platelet endothelial cell adhesion molecule (UniProt P16284; also known as CD31, EndoCAM, GPIIA′, PECA1, PECAM-1) is encoded by the PECAM1 gene (Gene ID 5175) in human
- PECAM-1 (CD31) is a 130kDa cell adhesion molecule that is expressed at the junctions of all continuous endothelia, as well as most bone marrow-derived hematopoietic cells, including platelets, monocytes, granulocytes and some lymphocytes
- The human PECAM1 and murine Pecam1 genes both produce multiple spliced isoforms with varying lengths in cytoplasmic domain, with the isoform Long being the major form expressed in human tissues and endothelial cells (ECs), and isoform delta 14-15 being the predominantly expressed murine form
- PECAM-1 plays an import role in maintaining vascular integrity and function by mediating ECs interactions with pericytes and smooth muscle cells (SMCs)
- PECAM-1 is initially produced with a signal peptide (human a.a
- 1-27, murine a.a
- 1-17) sequence, the removal of which yields the mature protein with a large extracellular region (human a.a
- 28-601, mouse a.a
- 18-590) composed of six C2-type Ig-like domains, followed by a transmembrane seqment (human a.a
- 602-620, mouse a.a
- 591-609) and a cytoplasmic tail (human a.a
- 621-738, mouse a.a
- 610-727) that plays an essential role in PECAM-1-mediated cellular signaling.