MABN1847MI
MilliporeSigma™ anti-Synapsin-1 Clone: MEGS3-10A,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1847MI-Each-of-1 | In Stock | ₹ 55,894.67 |
MABN1847MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,894.67
GST (18%): ₹ 10,061.041
Total Price: ₹ 65,955.711
Antigen
Synapsin-1
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
O88935
Host Species
Mouse
Purification Method
Purified by ion-exchange chromatography
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse
Form
Purified
Applications
Immunocytochemistry, Western Blot
Clone
MEGS3-10A
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
Syn1, Syn-1
Immunogen
Recombinant full-length mouse synapsin-1.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_038708.3
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG2b κ
Related Products
Description
- Specifically detects Synapsin-1 Clone: MEGS3-10A in Mouse samples, and it is validated for Immunocytochemistry, Western Blotting Synapsin-1 (UniProt O88935; also known as Synapsin I) is encoded by the Syn1 (also known as Syn-1) gene (Gene ID 20964) in murine species
- The synapins constitute a family of abundant neuronal phosphoproteins that regulate SV trafficking and neurotransmitter release at the pre-synaptic terminal
- Three genes exisit in mammals, encoding altogether 11 synapsin members by alternative splicings (Synapsin Ia & Ib by SYN1, Synapsin IIa & IIb by SYN2, Synapsin IIIa through IIIf by SYN3), Syn III is the most precociously expressed isoform that has a role in the early phases of neural development and is downregulated in mature neurons
- On the other hand, Syn I and Syn II are expressed at low levels at birth and their expressions progressively increase during synaptogenesis to reach a stable plateau at 1-2 months of life
- The NH2-terminal region is divided in A, B, and C domains and is highly conserved among synapsin isoforms
- Synapsins are regulated by postransloational phosphorylations
- Domain A contains PKA and CaMKI/IV phosphorylation sites, domain B contains MAPK/Erk phosphorylation sites, and domain C is phosphorylated by Src
- The c-terminal regions contain spliced domains and diverge among synapsin isoforms (domain D in Syn Ia and Ib, domain G in Syn Iia and Iib, domain H in Syn Iia, and domain J in Syn IIIa), although they all bear proline-rich regions binding to several SH3-containing proteins and additional phosphorylation sites for CaMKII, MAPK/Erk, and cdk1/5.