MABF933MI
MilliporeSigma™ anti-SAMHD1 Clone: I19-18,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF933MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABF933MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
SAMHD1
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q9Y3Z3
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
I19-18
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
SAMHD1, CHBL2, HDDC1, MOP5, SBBI88
Immunogen
GST-tagged recombinant full-length human SAMHD1.
Quantity
100 μg
Research Discipline
Inflammation, Immunology
Gene ID (Entrez)
NP_056289
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
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Description
- Specifically detects SAMHD1 Clone: I19-18 in Human samples, and it is validated for Flow Cytometry, Immunocytochemistry, Western Blotting Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (UniProt Q9Y3Z3; also known as DCIP, Dendritic cell-derived IFNG-induced protein, dNTPase, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1) is encoded by the SAMHD1 (also known as CHBL2, HDDC1, MOP5, SBBI88) gene (Gene ID 25939) in human
- The sterile alpha motif domain and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dGTP/GTP-activated deoxynucleotide (dNTP) triphosphohydrolase regulated by Cyclin A2/CDK1-dependent phosphorylation and is involved in balancing cellular dNTP pools
- SAMHD1 was originally identified as a disease gene associated with the rare infantile encephalopathy Aicardi-Goutières syndrome
- SAMHD1 was later shown to restrict HIV-1 replication in non-dividing myeloid-lineage cells and resting T cells by reducing the cellular dNTP concentration
- Simian immunodeficiency viruses (SIVs) are found to use their Vpx/Vpr accessory proteins to engage and modify host Cullin-RING-type E3 ubiquitin ligases substrate recognition to target SAMHD1 for poly-ubiquitylation and subsequent proteasomal degradation.