MABN812MI
MilliporeSigma™ Mouse anti-VPS4A, Clone: 14B1.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN812MI-Each-of-1 | In Stock | ₹ 40,633.84 |
MABN812MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,633.84
GST (18%): ₹ 7,314.091
Total Price: ₹ 47,947.931
Antigen
VPS4A
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
VPS4A; VPS4
Immunogen
GST-tagged recombinant protein corresponding to human VPS4A sequence at the N-terminus.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_037377
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
14B1.1
Gene Accession No.
Q9UN37
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Rat
Form
Purified
Related Products
Description
- Specifically detects VPS4A clone: 14B1.1 in Human, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6; UniProt Q9UN37; also known as hVPS4, Protein SKD2, SKD1-homolog, Vacuolar protein sorting factor 4A, Vacuolar sorting protein 4, VPS4A) is encoded by the VPS4A gene (also known as SKD1A, VPS4, VPS4-1) (Gene ID 27183) in human
- Vps4 is a member of the ATPases associated with various cellular activities
- The ESCRT (endosomal sorting complexes required for transport) machinery consists of five complexes (SCRT-0, ESCRT-I, ESCRT-II, ESCRT-III, and Vps4) that mediate multiple cellular membrane remodeling events, ranging from multivesicular bodies and exosomes formation to the final membrane abscission stage of cytokinesis, all of which converge in the scission of the narrow membrane neck that connects bud to parent membrane or daughter cell to daughter cell
- Scission depends on the polymerization of soluble ESCRT-III monomers or dimers into tightly membrane-bound filaments
- Vps4 is essential for ESCRT function in cells and it mediates the disassembly of ESCRT-III filaments to ensure a constant replenishing of the pool of soluble ESCRT-III monomers
- The ESCRTs are also exploited by HIV-1 and many other enveloped viruses for their escape from the host cells
- Vps4A is reported to facilitate the secretion of oncogenic miRNAs in exosomes and downregulation of Vps4A in hepatocellular carcinoma (HCC) is associated with tumor progression and metastasis.