MABS1154
MilliporeSigma™ Mouse anti-Derlin-1, Clone: 8G11.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1154-Each-of-1 | In Stock | ₹ 42,968.31 |
MABS1154 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
Derlin-1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
DERL1; DER1; UNQ243/PRO276
Immunogen
GST-tagged recombinant human derlin-1 C-terminal cytoplasmic fragment.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001128143
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2b κ
Applications
Immunocytochemistry, Western Blot
Clone
8G11.2
Gene Accession No.
Q9BUN8
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects Derlin-1 clone: 8G11.2 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting Derlin-1 (UniProt Q9BUN8; also known as Degradation in endoplasmic reticulum protein 1, Der1-like protein 1, DERtrin-1) is encoded by the DERL1 (also known as DER1) gene (ORF UNQ243/PRO276; Gene ID 79139) in human
- Derlins are integral ER membrane proteins that form homo-oligomers and heteromultimeric complexes with membrane-bound machinery, including the E3 ubiquitin ligase Hrd1 and its binding partner SEL1L, involved in ER-associated degradation (ERAD)
- Before ERAD substrates can be processed by the cytoplasmic ubiquitin-proteasome system, they need to be translocated across the ER membrane through an AAA ATPase p97/VCP-driven process
- Derlins are inactive members of the rhomboid family of intramembrane proteases that mediate the recruitment of AAA ATPase p97/VCP through interaction via their C-terminal SHP boxes
- Derlin-1 is proposed to contain four transmembrane segments (a.a
- 23-43, 60-80, 106-126, 155-175), three cytoplasmic domains (a.a
- 23-43, 60-80, 106-126, 155-175), and two lumenol (a.a
- 44-59 & 127-154) domains.