MilliporeSigma™ Potassium Channel Kir6.2, Mouse, Unlabeled, Clone: 10C1.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1704MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS1704MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Potassium Channel Kir6.2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q14654
Immunogen
KLH-conjugated linear peptide corresponding an N-terminal cytoplasmic domain sequence of human potassium channel Kir6.2.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_001159762
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
10C1.1
Conjugate
Unconjugated
Gene
KCNJ11, BIR, HHF2, MODY13, PNDM, TNDM3
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 10C1.1 targets human Kir6.2 N-terminal cytoplasmic region not present in the alternatively spliced isoform 2.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- ATP-sensitive inward rectifier potassium channel 11 (UniProt Q14654; also known as IKATP, Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11) is encoded by the KCNJ11 (also known as BIR, HHF2, MODY13, PNDM, TNDM3) gene (Gene ID 3767) in human
- Inward rectifier K+ channels (Kirs) modulate cell membrane potential and are classified as K+ transport channels (Kir1.x, Kir4.x, Kir5.x, Kir7.x), classic Kir (Kir2.x), G-protein-gated Kirs (Kir2.x and Kir3.x), and ATP-sensitive Kirs (Kir6.x)
- Kirs mediate diverse physiological functions of both excitable and nonexcitable epithelial cells, such as cell adhesion-migration, volume regulation, apoptosis, and proliferation
- ATP-sensitive potassium (K-ATP) channels are hetero-octamers composed of pore-forming Kir6.x (6.1 or 6.2) subunits and sulfonylurea receptor (SUR1 or SUR2) regulatory subunits
- K-ATP channels are regulated by intracellular ATP and ADP concentrations and are highly expressed in cardiomyocytes, where they play crucial roles in ischemic preconditioning (IPC)
- Potassium channel openers mimic the cardioprotection, while K-ATP channel blocker or Kir6.2-knockout is shown to abolish the effect of IPC in mice
- Human Kir6.2 is a 390-amino acid multi-pass membrane (a.a
- 69-93, 117-128, 145-166) protein that contains two small extraceullar regions (a.a
- 94-116 and 136-144) and a pore-forming domain (a.a
- 117-128), having both its N- and C-terminal exposed intracellularly (a.a
- 1-68 and a.a
- 167-390).