MABS1721
MilliporeSigma™ Potassium Channel Kir3.4, Mouse, Unlabeled, Clone: 8F4.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1721-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS1721 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Potassium Channel Kir3.4
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P48544
Immunogen
GST-tagged human potassium channel Kir3.4 C-terminal end fragment.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_000881
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
8F4.1
Conjugate
Unconjugated
Gene
KCNJ5, GIRK4, LQT13
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 8F4.1 detects human potassium channel Kir3.4 by targeting an epitope within the C-terminal cytoplasmic domain.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- G protein-activated inward rectifier potassium channel 4 (UniProt P48544; also known as Cardiac inward rectifier, CIR, Heart KATP channel, Inward rectifier K(+) channel Kir3.4, GIRK-4, IRK-4, KATP-1, Potassium channel, inwardly rectifying subfamily J member 5) is encoded by the KCNJ5 (also known as GIRK4, LQT13) gene (Gene ID 3762) in human
- Inward rectifier K+ channels (Kirs) modulate cell membrane potential and are classified as K+ transport channels (Kir1.x, Kir4.x, Kir5.x, Kir7.x), classic Kir (Kir2.x), G-protein-gated Kirs (Kir2.x and Kir3.x), and ATP-sensitive Kirs (Kir6.x)
- Kirs mediate diverse physiological functions of both excitable and nonexcitable epithelial cells, such as cell adhesion-migration, volume regulation, apoptosis, and proliferation
- While a large fraction of Kir3.4 (GIRK4; KCNJ5) subunits is processed to the cell membrane to form homomultimers, Kir3.4 subunits also assemble into heteromeric channels with Kir3.1 (GIRK1; KCNJ3) subunits in atrial myocytes or Kir3.2 (GIRK2; KCNJ6) in the cerebellum
- Upon agonist activation of appropriate GPCRs, heteroterameric Kir3.4 channels are opened via interaction with subunits of the pertussis toxin-sensitive class (Gi/o) G-proteins, resulting in membrane hyperpolarization and/or reduced excitability
- Whereas homotetrameric Kir3.4 channels can be activated by high intracellular Na+ independent of G-protein
- Human Kir3.4 is a 419-amino acid multi-pass membrane (a.a
- 87-111, 136-147, 164-185) protein that contains two small extraceullar regions (a.a
- 112-135 and 155-163) and a pore-forming domain (a.a
- 148-154), having both its N- and C-terminal ends exposed intracellularly (a.a
- 1-86 and a.a
- 186-419).