MilliporeSigma™ AdipoR2, Mouse, Unlabeled, Clone: 4D3.2,

Description

• Adiponectin receptor protein 2 (UniProt Q86V24; also known as Progestin and adipoQ receptor family member II) is encoded by the ADIPOR2 (also known as PAQR2) gene (Gene ID 79602) in human
• Adiponectin receptor protein 1 and 2 (AdipoR1 and AdipoR2) are receptors for adiponectin, a well knonwn anti-inflammatory adipokine highly abundant in serum
• Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively
• Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum adiponectin
• Adiponectin deficiency in mice is reported to exacerbate metabolic dysfunction by diet-induced obesity in some studies, while adiponectin overexpression alleviates metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity
• Adipor1-knockout (KO) results in increased adiposity and decreased glucose clearance in mice, whereas Adipor2-KO mice are lean and displayed improved glucose clearance
• In addition to its metabolic role, adiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction
• In a study of murine hind limb ischemia model, blood flow recovery after chronic hind limb ischemic surgery is similar among wild-type and AdipoR1-KO mice, while revascularization in AdipoR2-KO mice is severely attenuated
• Human AdipoR2 is a 7-transmembrane (a.a
• 148-168, 182-202, 214-234, 246-266, 274-294, 310-330, 349-369) protein with the opposite topology of G protein-coupled receptors (GPCRs), having its N-terminal end at the cytoplasmic side (a.a
• 1-147) and C-terminal end at the extracellular side (a.a
• 370-386)
• Unlike GPCRs also, adipoR1 and AdipoR2 transmembrane helices are not kinked or tilted relative to the plane of the membrane.