MABS458MI
MilliporeSigma™ Mouse anti-Betacellulin, Clone: 6G10.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS458MI-Each-of-1 | In Stock | ₹ 38,958.86 |
MABS458MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
Betacellulin
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
BTC
Immunogen
GST-tagged human recombinant full-length mature betacellulin.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001720
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry, Western Blot
Clone
6G10.1
Gene Accession No.
P35070
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects Betacellulin clone: 6G10.1 in Human samples, and it is validated for Immunohistochemistry, Western Blotting The human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein
- Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal
- Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4
- Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease
- Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment.