MilliporeSigma™ anti-LBPA Clone: 6C4,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT837MI-Each-of-1 | In Stock | ₹ 47,205.60 |
MABT837MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,205.60
GST (18%): ₹ 8,497.008
Total Price: ₹ 55,702.608
Antigen
LBPA
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
All species
Form
Purified
Applications
Dot Blot, Immunoassay, ELISA, Immunocytochemistry
Clone
6C4
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Immunogen
Endosomal membranes from baby hamster kidney fibroblasts (BHK) corresponding to Hamster LBPA.
Quantity
100 μg
Research Discipline
Cell Structure
Test Specificity
Clone 6C4 specifically detects LBPA, but not PC, PE, SM, PS, CL, PI, Sul, Chol, Cer, or CE purified from baby hamster kidney (BHK) cell lipid extract (Kobayahsi, T., et al. (1998). Nature. 392(6672):193-197).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Related Products
Description
- Specifically detects LBPA Clone: 6C4 in All samples, and it is validated for Dot Blot, Electron Microscopy, ELISA, Immunocytochemistry Lyso bis-phosphatidic acid (LBPA, Lysobisphosphatidic acid, L(bis)PA) is a lipid that is exclusively located in late endosomes and is used as a late endosome marker
- One of the characteristic features of late endosomes is a complex system of internal membranes within the lumen that contains large amounts of the unique, poorly degradable LBPA, and thus forms a specialized membrane domain within endosomes
- Late endosomes function not only as a major protein-sorting compartment, but also an obligatory station for LDL and other endocytosed ligands destined for degradation
- Research shows that the LBPA-rich membranes within late endosomes regulate cholesterol transport, presumably by acting as a collection and distribution device
- The genetic disease Niemann-Pick type C (NPC) is characterized by both lysosomal and endosomal storage disorders
- In skin fibroblasts from NPC patients, cholesterol accumulation is seen within vesicles containing late endosome markers LBPA and Rab7.