MilliporeSigma™ anti- HSPA8/Hsc70 Clone: N69,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1120MI-Each-of-1 | In Stock | ₹ 41,813.98 |
MABE1120MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
HSPA8/Hsc70
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P19120
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone N69 reacts with the constitutively expressed HSPA8/Hsc70 (HSC73), but not the heat schock-inducible HSP72 (Demidov, O.N., et al. (1999). Eur. J. Cardiothorac. Surg. 16(4):444-449).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
N69
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
HSPA8, HSC70
Immunogen
Co-purified Hsc73 and Hsp72 proteins from bovine skeletal muscle.
Quantity
100 μg
Research Discipline
Epigenetics, Nuclear Function
Gene ID (Entrez)
NP_776770
Target Species
Bovine, Human, Mouse, Rat
Form
Purified
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Description
- Specifically detects HSPA8/Hsc70 Clone: N69 in Bovine, Human, Mouse, Rat samples, and it is validated for Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blotting Heat shock cognate 71kDa protein (UniProt P19120; also known as Heat shock 70kDa protein 8, HSC70, HSC71, HSC73) is encoded by the HSPA8 (also known as HSC70, HSC73) gene (Gene ID 281831) in bovine species
- The mammalian HSP70 family consists of the mitochondrial HSP75, the endoplasmic HSP78, the cytoplasmic HSC70 (a.k.a
- HSC73 and HSP73) and its inducible counterpart HSP72 (a.k.a
- HSP70)
- The latter two have similar structures and properties, and both of them bind misfolded, newly synthesized polypeptides in an ATP-dependent manner, reflecting their chaperonic activity
- All cells constitutively express HSC70
- On the other hand, the expression of HSP72 in normal cells is mainly stress inducible, although constitutively high HSP72 expressions are observed in malignant human tumors of various origins
- The induced HSP72 expression enables stressed cells to better cope with the elevation of unfolded/denatured proteins and prevent apoptosis under various stress conditions.