Adiponectin Receptor 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1-059-Each-of-1 | In Stock | ₹ 47,926.50 |
PA1-059 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,926.50
GST (18%): ₹ 8,626.77
Total Price: ₹ 56,553.27
Antigen
Adiponectin Receptor 1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ADIPOR1
Gene Alias
2810031L11Rik; ACDCR1; adiponectin receptor 1; adiponectin receptor protein 1; Adipor1; CGI45; CGI-45; PAQR1; Parq1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I; TESBP1A
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
289036, 51094
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
Q96A54
Gene Symbols
ADIPOR1
Immunogen
Synthetic peptide corresponding to residues R(20) E A D T V E L A E L G P L L E E K(37) of human Adiponectin Receptor 1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-059 detects human and rat adiponectin receptor 1
- PA1-059 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽42 kDa protein corresponding to human adiponectin receptor 1 from transfected hepatocytes
- The PA1-059 immunogen is a synthetic peptide corresponding to residues R(20) E A D T V E L A E L G P L L E E K(37) of human Adiponectin Receptor 1
- Adiponectin (also known as 30- kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine
- Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes
- Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice
- Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes
- This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-
- Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning
- AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver
- These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors
- Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.