LXR alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1330-Each-of-1 | In Stock | ₹ 46,413.50 |
PA1330 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
LXR alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NR1H3
Gene Alias
AU018371; liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR; LXR alpha; Lxra; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10062
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
Q13133
Gene Symbols
NR1H3
Immunogen
Synthetic peptide corresponding to residues C D(318) F S Y N R E D F A K A(329) of human LXR alpha.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-330 detects recombinant human liver X receptor (LXR) alpha
- This antibody does not detect human recombinant LXR beta protein
- PA1-330 has been successfully used in ICC/IF and Western blot procedures
- By Western blot, this antibody detects an ∽64 kDa protein representing recombinant human LXR alpha
- The PA1-330 immunogen is a synthetic peptide corresponding to residues C D(318) F S Y N R E D F A K A(329) of human LXR alpha
- The PA1-330 immunizing peptide (Cat
- # PEP-114) is available for use in neutralization and control experiments
- NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity
- Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES
- LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides
- NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8
- It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.