Estrogen Receptor alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1309-Each-of-1 | In Stock | ₹ 51,887.00 |
PA1309 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,887.00
GST (18%): ₹ 9,339.66
Total Price: ₹ 61,226.66
Antigen
Estrogen Receptor alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ESR1
Gene Alias
DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2099, 24890, 397435
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P03372, P06211, Q29040
Gene Symbols
ESR1
Immunogen
Synthetic peptide corresponding to residues N(21) E L E P L N R P Q L K(32) C of human ER alpha.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Porcine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-309 detects estrogen receptor (ER) alpha from human, porcine and rat tissues and cells
- PA1-309 has been successfully used in Western blot, immunofluoresence and immunohistochemistry procedures
- By Western blot, this antibody detects an ∽64 kDa protein representing ER alpha from MCF-7 cell extracts
- Immunohistochemical staining of ER alpha in rat prostate with PA1-309 results in primarily nuclear staining
- The PA1-309 immunogen is a synthetic peptide corresponding to residues N(21) E L E P L N R P Q L K(32) C of human ER alpha
- This peptide sequence is completely conserved between human, rat, mouse, rabbit, sheep, porcine and bovine species
- PA1-309 immunizing peptide (Cat
- # PEP-037) is available for use in neutralization and control experiments
- Recombinant ER alpha expressed in baculovirus system (Cat
- # RP-310) can be purchased for control experiments in Western blot and gel shift assays
- Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors
- The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA
- When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins
- There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively)
- Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa))
- Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function
- They also play a role in other tissues such as bone
- Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.