GLRA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14661-Each-of-1 | In Stock | ₹ 49,083.50 |
PA14661 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,083.50
GST (18%): ₹ 8,835.03
Total Price: ₹ 57,918.53
Antigen
GLRA1
Classification
Polyclonal
Formulation
5mM Ammonium bicarbonate with no preservative; pH 7.4
Gene Accession No.
P07727, P23415, Q64018
Gene Symbols
GLRA1
Immunogen
Synthetic peptide corresponding to the N-terminal region of rat GLRA1 conjugated to KLH
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Gene
GLRA1
Gene Alias
GLRA; Glra1; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; glycine receptor alpha 1; glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; glycine receptor, alpha 1; glycine receptor, alpha 1 subunit; Glyr; GLYRA1; gra1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14654, 25674, 2741
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Related Products
Description
- This antibody is specific for the ∽48 kDa alpha 1 and alpha 2 subunits of the Glycine Receptor in Western blots of rat spinal cord and brain stem and in cell extracts, and does not recognize other Glycine Receptor subunits
- Immunolabeling is blocked by preadsorption of antibody with the peptide immunogen
- Reconstitute with 100 μL PBS
- GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system
- Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome
- Multiple transcript variants encoding different isoforms have been found for GLRA1
- Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine
- GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem
- Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.