Glucocorticoid Receptor Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1510A-Each-of-1 | In Stock | ₹ 48,460.50 |
PA1510A - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,460.50
GST (18%): ₹ 8,722.89
Total Price: ₹ 57,183.39
Antigen
Glucocorticoid Receptor
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Nr3c1
Gene Alias
cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038
Host Species
Rabbit
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat, Reptile
Product Type
Antibody
Isotype
IgG
Applications
Gel Shift, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum diluted in PBS with 0.05% sodium azide
Gene Accession No.
P04150, P06536, P06537
Gene Symbols
Nr3c1
Immunogen
Synthetic Peptide: A(150) P T E K E F P K T H S D V S S E Q Q H L K G Q T G(175)
Regulatory Status
RUO
Gene ID (Entrez)
14815, 24413, 2908
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- PA1-510A detects glucocorticoid receptor (GR) from human, rat, and reptile tissues
- This product detects both the unactivated and activated forms of the receptor
- PA1-510A has been successfully used in Western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunofluorescence, and gel shift procedures
- By Western blot, this antibody detects an ∽97 kDa protein representing GR from rat liver extract
- PA1-510A immunizing peptide corresponds to amino acid residues 150- 175 from human GR
- Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors
- Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins
- The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus
- Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart
- Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined
- Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance
- Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation
- GR binds to known steroids such as dexamethasone with nanomolar affinity