PDE6B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1722-Each-of-1 | In Stock | ₹ 44,811.50 |
PA1722 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,811.50
GST (18%): ₹ 8,066.07
Total Price: ₹ 52,877.57
Antigen
PDE6B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDE6B
Gene Alias
cGMP-phosphodiesterase beta-subunit; CSNB3; CSNBAD2; GMP-PDE beta; Mpb; PDE6B; PDEB; phosphodiesterase 6B; phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; phosphodiesterase 6B, cGMP-specific, rod, beta; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd1; rd-1; rd10; retinal degeneration 1; rod cGMP-phosphodiesterase beta-subunit; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; RP40
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18587, 5158
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P23440, P35913
Gene Symbols
PDE6B
Immunogen
Synthetic Peptides: H(20) Q Y F G (K/R) K L S P E N V A G A C(36)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-722 detects phosphodiesterase 6 beta (PDE6 beta) from mouse retinal extracts
- PA1-722 has been successfully used in Western blot procedures
- By Western blot, this antibody detects an ∽90 kDa protein representing PDE6 beta from mouse retinal extracts
- The PA1-722 immunizing peptides correspond to amino acid residues 20-36 from mouse and bovine PDE6 beta protein
- These peptides (Cat
- # PEP-183) are available for use in neutralization and control experiments
- The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways
- Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs)
- PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates
- PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system
- There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family)
- The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod
- The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.