HDAC4 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1863-Each-of-1 | In Stock | ₹ 46,502.50 |
PA1863 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
HDAC4
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HDAC4
Gene Alias
4932408F19Rik; AHO3; AI047285; BDMR; DKFZp779K1053; HA6116; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC-4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDAC-A; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0288; KIAA0744; MITR
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9759
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ChIP Assay, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P56524
Gene Symbols
HDAC4
Immunogen
Synthetic peptide corresponding to residues M(1)SSQSHPDGLSGRDQPVE(18) of human HDAC4
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-863 detects histone deacetylase 4 (HDAC4) from human cells
- PA1-863 has been successfully used in Western blot and ChIP procedures
- By Western blot, this antibody detects an ∽140 kDa protein representing HDAC4 from HeLa cell lysate
- An ∽110 kDa protein is also detected with PA1-863 which could correspond to protein degradation product
- PA1-863 immunogen is a synthetic peptide corresponding to residues M(1)SSQSHPDGLSGRDQPVE(18) of human HDAC4
- PA1-863 can be used with blocking peptide PEP-141 and blocking peptide PEP-095
- Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4)
- Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events
- Histone deacetylases act via the formation of large multiprotein complexes
- HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D
- It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer
- Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).