E6AP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA3843-Each-of-1 | In Stock | ₹ 47,926.50 |
PA3843 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,926.50
GST (18%): ₹ 8,626.77
Total Price: ₹ 56,553.27
Antigen
E6AP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
UBE3A
Gene Alias
4732496B02; 5830462N02Rik; A130086L21Rik; ANCR; AS; CTCL tumor antigen se37-2; E6AP; E6-AP; E6-AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; EPVE6AP; FLJ26981; HECT-type ubiquitin transferase E3A; HPVE6A; human papilloma virus E6-associated protein; human papillomavirus E6-associated protein; mKIAA4216; oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; UBE3A; ubiquitin conjugating enzyme E3A; ubiquitin protein ligase E3A; ubiquitin-protein ligase E3A
Host Species
Rabbit
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum diluted in PBS with 0.05% sodium azide
Gene Accession No.
Q05086
Gene Symbols
UBE3A
Immunogen
Full-length human E6-AP:GST fusion protein.
Regulatory Status
RUO
Gene ID (Entrez)
7337
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- PA3-843 detects Angelman Syndrome-Associated protein (E6-AP) from human tissues
- PA3-843 has been successfully used in Western blot and immunoprecipitation procedures
- By Western blot, this antibody detects a single ∽100 kDa protein representing E6-AP from HeLa cell lysate
- IMPORTANT: E6-AP is a very labile protein
- Freeze/thaw cycling of samples results in E6-AP degradation which is observed as a prominent 50 kDa band seen in Western blots
- PA3-843 antigen is bacterially expressed, full-length human E6-AP
- UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates
- Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B
- Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins
- UBE3A also plays an important role in the regulation of the circadian clock
- Defects in UBE3A are a cause of Angelman syndrome (AS).