Bcl-2 Monoclonal Antibody (100/D5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA511757-Each-of-1 | In Stock | ₹ 53,489.00 |
PIMA511757 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,489.00
GST (18%): ₹ 9,628.02
Total Price: ₹ 63,117.02
Antigen
Bcl-2
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
10mM PBS with 0.05% BSA and 0.05% sodium azide, pH 7.4
Gene Accession No.
P10415, P10417
Gene Symbols
Bcl2
Immunogen
A synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
100/D5
Conjugate
Unconjugated
Gene
Bcl2
Gene Alias
apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
12043, 596
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-11757 targets BCL-2 in FACS, ICC/IF, IHC (P), IP, and WB applications and shows reactivity with Human and mouse samples
- The MA5-11757 immunogen is a synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein
- BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death
- The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis
- Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2
- Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis
- Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells
- Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma
- In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative
- Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends
- The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.