PKC lambda/iota Monoclonal Antibody (F.699.5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA514874-Each-of-1 | In Stock | ₹ 53,133.00 |
PIMA514874 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,133.00
GST (18%): ₹ 9,563.94
Total Price: ₹ 62,696.94
Antigen
PKC lambda/iota
Classification
Monoclonal
Concentration
20 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
F1M7Y5, P41743, Q62074
Gene Symbols
PRKCI
Immunogen
Synthetic peptide corresponding to human PKC lambda/iota
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
F.699.5
Conjugate
Unconjugated
Gene
PRKCI
Gene Alias
2310021H13Rik; AI427505; aPKClambda; aPKC-lambda/iota; atypical protein kinase C-lambda/iota; DXS1179E; hypothetical protein; mKIAA4165; nPKC-iota; Pkci; Pkcl; PKClambda; PRKCI; Prkcl; PRKC-lambda/iota; protein kinase C iota; protein kinase C iota type; protein kinase C, iota; protein kinase C, lambda
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18759, 5584, 84006
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with other PKC isoforms
- The PKC family of serine/threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes
- This protein kinase is calcium-independent and phospholipid-dependent
- It is not activated by phorbolesters or diacylglycerol
- This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway
- This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis
- There is a single exon pseudogene mapped on chromosome X.