ROR1 Monoclonal Antibody (2H6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515539-Each-of-1 | In Stock | ₹ 52,287.50 |
PIMA515539 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,287.50
GST (18%): ₹ 9,411.75
Total Price: ₹ 61,699.25
Antigen
ROR1
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
Q01973
Gene Symbols
ROR1
Immunogen
Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
Regulatory Status
RUO
Gene ID (Entrez)
4919
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Immunocytochemistry, Western Blot
Clone
2H6
Conjugate
Unconjugated
Gene
ROR1
Gene Alias
2810404D04Rik; dJ537F10.1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; mRor1; neurotrophic tyrosine kinase, receptor related 1; neurotrophic tyrosine kinase, receptor-related 1; Ntrkr1; receptor tyrosine kinase like orphan receptor 1; receptor tyrosine kinase-like orphan receptor 1; RGD1559469; ROR1; T-ROR1; tyrosine-protein kinase transmembrane receptor ROR1
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15539 targets ROR1 in indirect ELISA, IF and WB applications and shows reactivity with Human samples
- The MA5-15539 immunogen is recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
- MA5-15539 detects ROR1 which has a predicted molecular weight of approximately 101kDa
- Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival
- Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma
- First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "eorphan"e receptor due to the fact its related ligand remained elusive
- Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT
- ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.