PIMA515648
IHOG Monoclonal Antibody (3G8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515648-Each-of-1 | In Stock | ₹ 50,151.50 |
PIMA515648 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,151.50
GST (18%): ₹ 9,027.27
Total Price: ₹ 59,178.77
Antigen
IHOG
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
Q9VM64
Gene Symbols
ihog
Immunogen
Purified recombinant fragment of human IHOG expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
33972
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Western Blot
Clone
3G8
Conjugate
Unconjugated
Gene
ihog
Gene Alias
CG9211; CG9211-PA; CT26314; Dmel\ ihog; Dmel\CG9211; Dmel_CG9211; GH03927p; Ihog; ihog-PA; interference hedgehog
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Drosophila, Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15648 targets IHOG in indirect ELISA, WB applications and shows reactivity with Drosophila samples
- The MA5-15648 immunogen is purified recombinant fragment of human IHOG expressed in E
- Coli
- MA5-15648 detects IHOG which has a predicted molecular weight of approximately 98kDa
- The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal
- ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc)
- The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc
- Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.