LSD1 Monoclonal Antibody (1E5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524875-Each-of-1 | In Stock | ₹ 47,837.50 |
PIMA524875 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,837.50
GST (18%): ₹ 8,610.75
Total Price: ₹ 56,448.25
Antigen
LSD1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
KDM1A
Gene Alias
1810043O07Rik; AA408884; amine oxidase (flavin containing) domain 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; CPRF; D4Ertd478e; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; KDM1; KDM1A; KIAA0601; Lsd1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine demethylase 1A; lysine-specific demethylase 1; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A; mKIAA0601; neuroprotective protein 3; RGD1562975; RP1-184J9.1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06
Host Species
Mouse
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23028
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
1E5
Formulation
0.1M tris glycine with 50% glycerol and 0.2% sodium azide; pH 7.4
Gene Accession No.
O60341
Gene Symbols
KDM1A
Immunogen
Purified recombinant human KDM1A protein fragments expressed in E.coli.
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human, Non-human Primate
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
- LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor
- LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain
- This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase
- It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed
- LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3
- This protein may play a role in the repression of neuronal genes
- Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity
- It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes
- Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.