VEGF Receptor 1 Monoclonal Antibody (CL0345), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA534979-Each-of-1 | In Stock | ₹ 49,884.50 |
PIMA534979 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,884.50
GST (18%): ₹ 8,979.21
Total Price: ₹ 58,863.71
Antigen
VEGF Receptor 1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
FLT1
Gene Alias
AI323757; embryonic receptor kinase 2; Emrk2; FLT; FLT1; FLT-1; fms related tyrosine kinase 1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; i21; sFlt1; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2321
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Clone
CL0345
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P17948
Gene Symbols
FLT1
Immunogen
Recombinant Protein corresonding to Human VEGF Receptor 1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Related Products
Description
- Immunogen sequence: LNLTIMNVSL QDSGTYACRA RNVYTGEEIL QKKEITIRDQ EAPYLLRNLS DHTVAISSST TLDCHANGVP EPQITWFKNN HKIQQEPGII LGPGSSTLFI ERVTEEDEGV YHCKATNQKG S FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis
- Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing
- May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells
- Can promote endothelial cell proliferation, survival and angiogenesis in adulthood
- Its function in promoting cell proliferation seems to be cell-type specific
- Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro)
- Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.