Desmin Recombinant Rabbit Monoclonal Antibody (SI18-00), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532068-Each-of-1 | In Stock | ₹ 48,905.50 |
PIMA532068 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
Desmin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P17661, P31001, P48675
Gene Symbols
DES, desma, desmb
Immunogen
Synthetic peptide within Human Desmin aa 421-470
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat, Zebrafish
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Western Blot
Clone
SI18-00
Conjugate
Unconjugated
Gene
DES
Gene Alias
CMD1I, CSM1, CSM2, DES, Desmin, desmin-like protein, FLJ12025, FLJ39719, FLJ41013, FLJ41793, I79_018932, intermediate filament protein, LGMD2R, MFM1, muscle-specific intermediate filament desmin, muscle-specific intermediate filament protein, mutant desmin p.K241E, SCPNK, similar to desmin
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
13346, 1674, 30148, 64362, 768287
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle)
- Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation
- In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk
- The expression pattern of desmin in smooth muscle is much more heterogenous
- Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e
- rhabdomyosarcomas and leiomyosarcomas
- Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.