Phospho-PAK1/2/3 (Ser144, Ser141, Ser139) Recombinant Rabbit Monoclonal Antibody (SU03-70), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532130-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532130 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Phospho-PAK1/2/3 (Ser144, Ser141, Ser139)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O75914, O88643, P35465, Q13153, Q13177, Q61036, Q62829, Q64303, Q8CIN4
Gene Symbols
Pak1, PAK2, PAK3
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser144 of Human PAK1 aa 121-150
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SU03-70
Conjugate
Unconjugated
Gene
Pak1
Gene Alias
5330420P17Rik, A130002K10Rik, activated protein kinase alpha, ADRB2, adriamycin resistance-associated, AI836325, Alpha-PAK, ARA, AW045634, Beta-PAK, bPAK, CDC42/RAC effector kinase PAK-A, CDC42/RAC effector kinase PAK-B, CDKN1A, C-t-PAK2, D16Ertd269e, EC 2.7.11.1, gamma pak, gamma-PAK, hPAK3, kinase PAK1, mKIAA4182, MRX30, MRX47, oligophrenin-3, OPHN3, p21 (CDKN1A)-activated kinase 1, p21 (CDKN1A)-activated kinase 2, p21 (CDKN1A)-activated kinase 3, p21 (RAC1) activated kinase 1, p21 (RAC1) activated kinase 2, p21 (RAC1) activated kinase 3, p21 protein (Cdc42/Rac)-activated kinase 1, p21 protein (Cdc42/Rac)-activated kinase 2, p21 protein (Cdc42/Rac)-activated kinase 3, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast), p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related), p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related), p21-activated kinase 1, p21-activated kinase 2, p21-activated kinase 3, p27, p34, p58, p65-PAK, p68-PAK, PAK 1, PAK alpha, PAK beta, PAK gamma, Pak1,
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18479, 18481, 224105, 29431, 29432, 29433, 5058, 5062, 5063
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003)
- Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004)
- PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998)
- Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).