CD230 (PrP) Recombinant Rabbit Monoclonal Antibody (SC57-05), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532202-Each-of-1 | In Stock | ₹ 50,418.50 |
PIMA532202 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,418.50
GST (18%): ₹ 9,075.33
Total Price: ₹ 59,493.83
Antigen
CD230 (PrP)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
F7VJQ1, P04156, P04925, P13852
Gene Symbols
PRNP
Immunogen
Synthetic peptide within Human Prion Protein aa 200-249
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SC57-05
Conjugate
Unconjugated
Gene
PRNP
Gene Alias
AA960666, AI325101, Alternative prion protein, alternative prion protein, major prion protein, AltPrP, ASCR, BSE, CD230, CD230 antigen, CJD, GSS, KURU, major prion protein, major prion protein, alternative prion protein, major scrapie-associated fibril protein 1, MGC26679, p27-30, PK resistant core, prion protein, prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia), prion protein precursor, prion protein precursor PrP, prion protein PrP, prion protein variant a, prion protein variant b, prion protein, PrP, prion protein, structural, prion-related protein, PRIP, Prn, Prn-i, Prnp, Prn-p, PrP, PrP<C>, PrP27-30, PrP33-35C, PrPc, PrPSc, Sinc, SIP, TSE
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19122, 24686, 5621
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule
- PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes
- Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD)
- Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.