IkB beta Recombinant Rabbit Monoclonal Antibody (SN0648), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532261-Each-of-1 | In Stock | ₹ 59,185.00 |
PIMA532261 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,185.00
GST (18%): ₹ 10,653.30
Total Price: ₹ 69,838.30
Antigen
IkB beta
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q15653
Gene Symbols
NFKBIB
Immunogen
Synthetic peptide within Human IKB beta aa 322-356
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN0648
Conjugate
Unconjugated
Gene
NFKBIB
Gene Alias
I kappa B beta, I(Kappa)B(beta), ikappaBbeta, I-kappa-B-beta, IkB, IKB B, IKB beta, Ikbb, ikB-B, IkBbeta, ikB-beta, NF kappa BIB, NF-kappa-B inhibitor beta, NF-kappa-BIB, NFKB inhibitor beta, NFKBIB, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta, Thyroid receptor, thyroid receptor-interacting protein 9, TR-interacting protein 9, TRIP 9, TRIP9, TRIP-9
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4793
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins
- Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB
- The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits
- IKK alpha and IKK beta serve as the catalytic subunits of the kinase and IKK gamma serves as the regulatory subunit
- Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.