IKK epsilon Recombinant Rabbit Monoclonal Antibody (JU06-72), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532807-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532807 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
IKK epsilon
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q14164, Q9R0T8
Gene Symbols
IKBKE
Immunogen
Synthetic peptide within Human IKBKE aa 26-75
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JU06-72
Conjugate
Unconjugated
Gene
IKBKE
Gene Alias
AW558201, I-kappa-B kinase epsilon, Ikbke, IKKE, IKK-E, IKKepsilon, IKK-epsilon, IKKI, IKK-i, IKK-related kinase epsilon, inducible I kappa-B kinase, inducible IkappaB kinase, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, inhibitor of kappaB kinase epsilon, inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151, RP11-534L20.1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
56489, 9641
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- IKBKE is an activator of nuclear factor-kappa-B
- Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death
- NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
- NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli
- NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity
- Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma
- A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i
- IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1
- IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.