IKK alpha/beta Recombinant Rabbit Monoclonal Antibody (SN63-02), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532274-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532274 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
IKK alpha/beta
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O14920, O15111, O88351, Q60680, Q9QY78
Gene Symbols
CHUK, Ikbkb
Immunogen
Recombinant protein within Human IKK beta aa 450-652
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot, Western Blot
Clone
SN63-02
Conjugate
Unconjugated
Gene
CHUK
Gene Alias
AI132552, AI256658, AIM-1, CHUK, Chuk1, component of inhibitor of nuclear factor kappa B kinase complex, conserved helix-loop-helix ubiquitous kinase, EC 2.7.11.10, Fbx24, Fbxo24, I kappa B kinase 1, i kappa-B kinase alpha, IkappaB kinase, I-kappa-B kinase 1, I-kappa-B kinase 2, IkappaB kinase alpha, I-kappa-B kinase alpha, I-kappa-B kinase-alpha, I-kappa-B-kinase beta, IkB kinase alpha subunit, IkB kinase-alpha, IkB kinase-beta, ikBKA, Ikbkb, IKK alpha, IKK[b], IKK1, IKK2, IKK-2, IKKA, IKK-A, IKK-a kinase, IKK-alpha, Ikkb, IKK-B, IKKbeta, IKK-beta, IMD15, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of kappaB kinase beta, inhibitor of nuclear factor kappa B kinase beta subunit, inhibitor of nuclear factor kappa B kinase subunit beta, inhibitor of nuclear factor kappa-B kinase subunit alpha, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKA, NFKBIKB, Nuclear factor NFkappaB inhibitor kinase alpha, nuclear factor NF-kappa-B inhibitor kinase alpha, Nuclear factor NF-kappa-B inhibitor kinase beta, TCF16, TCF-16, TCF17, Transcription factor 16
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1147, 12675, 16150, 309361, 3551, 84351
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans
- Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins
- This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus
- Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.