ACE2 Recombinant Rabbit Monoclonal Antibody (SN0754), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532307-Each-of-1 | In Stock | ₹ 49,261.50 |
PIMA532307 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,261.50
GST (18%): ₹ 8,867.07
Total Price: ₹ 58,128.57
Antigen
ACE2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
Q5EGZ1, Q8R0I0, Q9BYF1
Gene Symbols
ACE2
Immunogen
Synthetic peptide within Human ACE2 aa 181-230
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SN0754
Conjugate
Unconjugated
Gene
ACE2
Gene Alias
2010305L05Rik, ACE 2, Ace2, ACEH, ACE-related carboxypeptidase, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, angiotensin I converting enzyme 2, angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, anigotensin I converting enzyme 2, anigotensin-converting enzyme-related carboxypeptidase, metalloprotease MPROT15, peptidyl-dipeptidase A, Processed angiotensin-converting enzyme 2, renal angiotensin-converting enzyme 2, UNQ868/PRO1885
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
302668, 59272, 70008
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology
- In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis
- Recently
- ACE2 has also been shown to be a functional receptor of the SARS coronavirus
- The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII
- While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.