Cdc34 Recombinant Rabbit Monoclonal Antibody (JJ086-07), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532420-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532420 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Cdc34
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P49427, Q8CFI2
Gene Symbols
CDC34
Immunogen
Recombinant protein within Human Cdc34 aa 1-236
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Western Blot, Western Blot
Clone
JJ086-07
Conjugate
Unconjugated
Gene
CDC34
Gene Alias
(E3-independent) E2 ubiquitin-conjugating enzyme R1, AI327276, CDC34, cell division cycle 34, cell division cycle 34 homolog, E2 ubiquitin-conjugating enzyme R1, E2-CDC34, serine protease, UBC3, UBCH3, UBE2R1, ubiquitin carrier protein, ubiquitin conjugating enzyme E2 R1, ubiquitin-conjugating enzyme Cdc34, ubiquitin-conjugating enzyme E2 R1, Ubiquitin-conjugating enzyme E2-32 kDa complementing, ubiquitin-conjugating enzyme E2-CDC34, Ubiquitin-protein ligase R1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
216150, 299602, 997
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins
- In vitro catalyzes 'Lys-48'-linked polyubiquitination
- Cooperates with the E2 UBCH5C and the SCF (FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation
- Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin
- UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin
- Cooperates with the SCF (SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1
- Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles
- Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation
- Also involved in the degradation of beta-catenin
- Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.