RARA Recombinant Rabbit Monoclonal Antibody (SN0725), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532325-Each-of-1 | In Stock | ₹ 47,837.50 |
PIMA532325 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,837.50
GST (18%): ₹ 8,610.75
Total Price: ₹ 56,448.25
Antigen
RARA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P10276, P11416
Gene Symbols
RARA
Immunogen
Synthetic peptide within Human Retinoic Acid Receptor alpha aa 1-50
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Western Blot
Clone
SN0725
Conjugate
Unconjugated
Gene
RARA
Gene Alias
Nr1b1, nuclear receptor subfamily 1 group B member 1, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form, RAR, RAR Alpha, RAR alpha 1, RARA, RAR-alpha, RARalpha1, retinoic acid, retinoic acid nuclear receptor alpha variant 1, retinoic acid nuclear receptor alpha variant 2, retinoic acid receptor, retinoic acid receptor alpha, retinoic acid receptor, alpha, retinoic acid receptor, alpha polypeptide, RRA
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19401, 5914
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- RARA is a receptor for retinoic acid
- Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes
- The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5
- In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression
- On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation
- RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis
- Has a role in the survival of early spermatocytes at the beginning prophase of meiosis
- In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes
- In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function
- Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5
- Mediates retinoic acid-induced granulopoiesis.