Phospho-c-Raf (Ser621) Recombinant Rabbit Monoclonal Antibody (JJ085-05), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532438-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532438 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Phospho-c-Raf (Ser621)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P04049, P11345, Q99N57
Gene Symbols
Raf1
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser621 of Human Raf1 aa 591-640
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
JJ085-05
Conjugate
Unconjugated
Gene
Raf1
Gene Alias
6430402F14Rik, AA990557, BB129353, CMD1NN, CRAF, C-RAF, C-Raf proto-oncogene, serine/threonine kinase, Craf1, Craf1 transforming, D830050J10Rik, EC 2.7.11.1, kinase Raf1, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV), murine sarcoma 3611 oncogene 1, NS5, Oncogene RAF1, OTTHUMP00000207813, OTTHUMP00000209389, proto-oncogene c-RAF, RAF, raf proto-oncogene serine/threonine protein kinase, RAF proto-oncogene serine/threonine-protein kinase, RAF1, Raf-1, Raf-1 proto-oncogene, serine/threonine kinase, sarcoma 3611 oncogene, v-Raf, v-raf-1 leukemia viral oncogene 1, vraf1 murine le, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1, v-raf-leukemia viral oncogene 1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
110157, 24703, 5894
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly
- Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2
- Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration
- Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.