Phospho-SRC (Tyr419) Recombinant Rabbit Monoclonal Antibody (ST0800), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532143-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA532143 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Phospho-SRC (Tyr419)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P05480, P12931, Q9WUD9
Gene Symbols
SRC
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Tyr419 of Human Src aa 401-450
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Western Blot
Clone
ST0800
Conjugate
Unconjugated
Gene
SRC
Gene Alias
ASV, AW259666, csrc, c-SRC, c-src protein, C terminus, EC 2.7.10.2, fc54g04, Neuronal proto-oncogene tyrosine-protein kinase Src, non-tyrosine protein kinase, ORF, OTTHUMP00000174476, OTTHUMP00000174477, OTTHUMP00000174478, p60-Src, p60-Src-1, PP60C-SCR, pp60c-src, pp60src, pp60v-src, protein-tyrosine kinase, proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, Proto-oncogene tyrosine-protein kinase Src, Rous sarcoma oncogene, RP5-823N20.1, sb:cb864, SDR, src, src downstream region, src oncogene, SRC proto-oncogene, non-receptor tyrosine kinase, SRC proto-oncogene, non-receptor tyrosine kinase L homeolog, SRC proto-oncogene, non-receptor tyrosine kinase S homeolog, src.L, src.S, SRC1, src-1, src1-A, src-a, src-b, THC6, transforming protein, tyrosine kinase pp60c-src, tyrosine protein kinase c-src, tyrosine protein kinase pp60-c-src, tyrosine-protein kinase SRC-1, Unknown, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogen
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
20779, 6714, 83805
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth
- SRC is involved in the regulation of growth and differentiation of eukaryotic cells
- SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis
- In humans, the gene encoding SRC is present on chromosome 20
- Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects
- Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity
- Mutations in the SRC gene could be involved in the malignant progression of colon cancer
- Two transcript variants encoding the same SRC protein have been found thus far.