Doublecortin Recombinant Rabbit Monoclonal Antibody (JJ0959), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532495-Each-of-1 | In Stock | ₹ 53,088.50 |
PIMA532495 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,088.50
GST (18%): ₹ 9,555.93
Total Price: ₹ 62,644.43
Antigen
Doublecortin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O43602, O88809, Q9ESI7
Gene Symbols
DCX
Immunogen
Synthetic peptide within Human Doublecortin aa 22-71
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Western Blot
Clone
JJ0959
Conjugate
Unconjugated
Gene
DCX
Gene Alias
DBCN, Dbct, DC, Dcn, DCX, doublecortex, doublecortin, doublin, lissencephalin-X, lissencephaly, X-linked (doublecortin), LISX, Lis-X, LIS-XD, Neuronal migration protein doublecortin, OTTHUMP00000023860, OTTHUMP00000216316, SCLH, XLIS
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
13193, 1641, 84394
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation
- DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules
- It contains two doublecortin domains, which bind microtubules
- In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex
- Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.