IRAK2 Recombinant Rabbit Monoclonal Antibody (JG36-23), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA534746-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA534746 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
IRAK2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
O43187
Gene Symbols
IRAK2
Immunogen
Recombinant protein within Human IRAK2 aa 30-270
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
JG36-23
Conjugate
Unconjugated
Gene
IRAK2
Gene Alias
6330415L08Rik; AI649099; interleukin 1 receptor associated kinase 2; interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase 2c; interleukin-1 receptor-associated kinase-like 2; Irak2; IRAK-2; MGC150550; mu-IRAK-2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3656
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Form
Liquid
Related Products
Description
- Positive Control: PC-3M, A549, HepG2, Jurkat, human tonsil tissue, human prostate cancer tissue, human heart tissue
- IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization
- The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP)
- IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, which is a pivotal transcription factor mediating inflammatory and immune response
- A novel member in the IRAK/Pelle family was recently identified and designated IRAK2
- Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation
- IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation
- Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS
- IRAK2 is expressed in a variety of human tissues.