ELK1 Recombinant Rabbit Monoclonal Antibody (ARC0339), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535227-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA535227 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ELK1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
A4GTP4, P19419, P41969
Gene Symbols
ELK1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 329-428 of human ELK1 (NP_0011075951)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunoprecipitation, Western Blot
Clone
ARC0339
Conjugate
Unconjugated
Gene
ELK1
Gene Alias
ELK 1; ELK1; Elk-1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS transcription factor ELK1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13712, 2002, 314436
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- Immunogen sequence: GGPGPERTPG SGSGSGLQAP GPALTPSLLP THTLTPVLLT PSSLPPSIHF WSTLSPIAPR SPAKLSFQFP SSGSAQVHIP SISVDGLSTP VVLSPGPQKP ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors
- ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus
- Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1
- ELK1 appears to be a direct target of activated MAP kinase
- Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo
- ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade
- Alternatively spliced transcript variants encoding the same protein have been found for ELK1.