Phospho-DARPP-32 (Ser102) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104587-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104587 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-DARPP-32 (Ser102)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ppp1r1b
Gene Alias
AU040756; DARPP32; DARPP-32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine and cAMP-regulated neuronal phosphoprotein 32; dopamine- and cAMP-regulated phosphoprotein DARPP-32; FLJ20940; IPPD; neuronal phosphoprotein DARPP-32; OTTHUMP00000164275; OTTHUMP00000164276; Ppp1r1b; PPR1B; protein pho; protein phosphatase 1 regulatory inhibitor subunit 1B; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19049, 360616, 84152
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q60829, Q6J4I0, Q9UD71
Gene Symbols
Ppp1r1b
Immunogen
A synthesized peptide derived from human PPP1R1B(Accession Q9UD71), corresponding to amino acid residues around phosphorylated Ser102.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of DARPP32 only when phosphorylated at Ser102, which site historically referenced as Ser97
- DARPP-32 is a dopamine (DA) and AMP-regugated ∽32 kDa phosphoprotein that is associated with dopaminoceptive neurons
- The protein inhibits Protein Phosphatase I when it is phosphorylated on Thr34
- In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA
- Phosphorylation of DARPP-32 is thought to play a critical role in the regugation of dopaminergic neurotransmission
- In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.