Phospho-Bcr (Tyr360) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104787-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104787 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-Bcr (Tyr360)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Bcr
Gene Alias
5133400C09Rik; ABL; AI561783; AI853148; ALL; BCR; BCR activator of RhoGEF and GTPase; BCR protein; BCR, RhoGEF and GTPase activating protein; bcr/abl; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region homolog; breakpoint cluster region protein; c-ABL; c-abl oncogene 1; CML; D22S11; D22S662; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; Kiaa3017; mKIAA3017; p150; PHL; renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
110279, 309696, 613
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P11274, Q6PAJ1
Gene Symbols
Bcr
Immunogen
A synthesized peptide derived from human BCR(Accession P11274), corresponding to amino acid residues around phosphorylated Tyr360.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of Bcr only when phosphorylated at Tyrosine 360
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia
- The chromosome 22 breakpoint for this translocation is located within the BCR gene
- The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint
- Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear
- The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac
- Two transcript variants encoding different isoforms have been found for this gene.