Phospho-Bcl-xL (Thr47) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104974-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104974 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-Bcl-xL (Thr47)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BCL2L1
Gene Alias
anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12048, 24888, 598
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P53563, Q07817, Q64373
Gene Symbols
BCL2L1
Immunogen
A synthesized peptide derived from human BCL2L1(Accession Q07817), corresponding to amino acid residues around phosphorylated Thr47.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of BCL-XL only when phosphorylated at Threonine 47
- BCL-XL is a part of the BCL-2 protein family
- BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities
- BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening
- VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis
- Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported
- The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.