PIPA5105062
Phospho-RyR3 (Ser160) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105062-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105062 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-RyR3 (Ser160)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RYR3
Gene Alias
AI851294; Brain ryanodine receptor-calcium release channel; brain-type ryanodine receptor; C230090H21; calcium release channel; HBRR; Ryanodine receptor 3; RYR3; RYR-3; Type 3 ryanodine receptor
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20192, 6263
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
A2AGL3, Q15413
Gene Symbols
RYR3
Immunogen
A synthesized peptide derived from human RYR3(Accession Q15413), corresponding to amino acid residues around phosphorylated Ser160.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of RYR3 only when phosphorylated at Ser160
- RYR3 is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes
- RYR3 is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules
- Two transcript variants encoding different isoforms of RYR3 have been found
- RYR3 mediates calcium channel release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and plays a role in triggering muscle contraction
- Further, RYR3 may also regulate Ca(2+) release by other calcium channels, as well as Ca(2+) release from the endoplasmic reticulum in non-muscle cells
- RYR3 also contributes to cellular calcium ion homeostasis
- Plays a role in cellular calcium signaling
- Diseases associated with RYR3 include Central Core Disease and Arrhythmogenic Right Ventricular Dysplasia 2.